Region-specific diversification of the highly virulent serotype 1 Streptococcus pneumoniae. Issue 2 (11th August 2015)

• Record Type: Journal Article
• Authors: Cornick, Jennifer E.; Chaguza, Chrispin; Harris, Simon R.; Yalcin, Feyruz; Senghore, Madikay; Kiran, Anmol M.; Govindpershad, Shanil; Ousmane, Sani; Plessis, Mignon Du; Pluschke, Gerd; Ebruke, Chinelo; McGee, Lesley; Sigaùque, Beutel; Collard, Jean-Marc; Antonio, Martin; von Gottberg, Anne; French, Neil; Klugman, Keith P.; Heyderman, Robert S.; Bentley, Stephen D.; Everett, Dean B.
• Is Part Of: Microbial genomics. Volume 1:Issue 2(2015)
• Publication Date: 2015-08-11
• Subjects: Pneumococcal Disease -- Genomics -- Phylogeny -- Africa -- Recombination -- Antibiotic Resistance -- PAGe; Microbial genomics -- Periodicals; 572.8629
• DOI: 10.1099/mgen.0.000027
• Languages: English
• ISSNs: 2057-5858

Abstract

Abstract : Serotype 1 Streptococcus pneumoniae is a leading cause of invasive pneumococcal disease (IPD) worldwide, with the highest burden in developing countries. We report the whole-genome sequencing analysis of 448 serotype 1 isolates from 27 countries worldwide (including 11 in Africa). The global serotype 1 population shows a strong phylogeographic structure at the continental level, and within Africa there is further region-specific structure. Our results demonstrate that region-specific diversification within Africa has been driven by limited cross-region transfer events, genetic recombination and antimicrobial selective pressure. Clonal replacement of the dominant serotype 1 clones circulating within regions is uncommon; however, here we report on the accessory gene content that has contributed to a rare clonal replacement event of ST3081 with ST618 as the dominant cause of IPD in the Gambia.