Two new farnesyl phenolic compounds with anti-inflammatory activities from Ganoderma duripora. (15th October 2018)

• Record Type: Journal Article
• Authors: Liu, Jie-Qing; Lian, Chen-Lei; Hu, Tian-Yong; Wang, Cui-Fang; Xu, Ying; Xiao, Lei; Liu, Zhi-Qiang; Qiu, Shu-Qi; Cheng, Bao-Hui
• Is Part Of: Food chemistry. Volume 263(2018)
• Page Start: 155
• Page End: 162
• Publication Date: 2018-10-15
• Subjects: Farnesyl phenol -- Ganoderma duripora -- Anti-inflammation -- COX-2 -- MAPK -- NF-κB; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2018.04.097
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Two new farnesyl phenolic compounds, ganoduriporols A and B (1 and2 ) were isolated from fungus Ganoderma duripora, and they exhibited significant anti-inflammatory effect at concentrations ranging from 1 to 8 μM in LPS-induced RAW 264.7 macrophages. Ganoduriporols A inhibit the production of TNF-α, IL-1β, IL-6 and PGE2 in a dose-dependent manner through the suppression of COX-2, MAPK and NF-κB signaling pathway in LPS-induced RAW 264.7 macrophages. Highlights: Two new farnesyl phenolic compounds were isolated from Ganoderma duripora . These compounds exhibited anti-inflammatory effect in LPS-induced RAW 264.7 cells. These compounds inhibit the production of TNF-α, IL-1β, IL-6 and PGE2 . Compound1 inhibited COX-2, MAPK and NF-κB signaling pathway. Abstract: Ganoderma fungi have long been used as a famous traditional medicine and food in country of East Asia. In this work, two new farnesyl phenolic compounds, ganoduriporols A and B (1 and2 ), were isolated from the fruiting bodies of Ganoderma duripora, and their structures were elucidated using various spectroscopic methods. Anti-inflammatory activities were assayed and evaluated for the two compounds. Ganoduriporols A and B exhibited dose-dependent anti-inflammatory effects in RAW 264.7 cells. Furthermore, ganoduriporol A was demonstrated to inhibit the production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and prostaglandin E2 (PGE2 ) through the suppression of COX-2, MAPK and NF-κB signaling pathway in LPS-induced macrophage cells. These results suggested that these two new farnesyl phenolic compounds and the fruiting body of G. duripora could serve as anti-inflammatory agents for medicinal use or functional food.