Sea buckthorn seed oil reduces blood cholesterol and modulates gut microbiota. Issue 9 (21st August 2019)

• Record Type: Journal Article
• Authors: Hao, Wangjun; He, Zouyan; Zhu, Hanyue; Liu, Jianhui; Kwek, Erika; Zhao, Yimin; Ma, Ka Ying; He, Wen-Sen; Chen, Zhen-Yu
• Is Part Of: Food & function. Volume 10:Issue 9(2019)
• Page Start: 5669
• Page End: 5681
• Publication Date: 2019-08-21
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c9fo01232j
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Sea buckthorn seed oil favorably decreases plasma cholesterol. Abstract : Sea buckthorn seed oil (SBSO) has been used as a functional food in the prevention of heart diseases. The present study investigates the effects of SBSO on blood cholesterol and the gut microbiota in hypercholesterolemia hamsters. Four groups of hamsters ( n = 8 each) were given one of four diets, namely a non-cholesterol control diet (NCD), a high-cholesterol control diet (HCD) containing 0.1% cholesterol, and an HCD diet with sea buckthorn seed oil replacing 50% lard (SL) or replacing 100% lard (SH). Feeding SL and SH diets could reduce blood total cholesterol by 20–22%. This was accompanied by the down-regulation of the gene expression of acyl-CoA:cholesterol acyltransferase 2 (ACAT2), microsomal triacylglycerol transport protein (MTP), and ATP-binding cassette transporter8 (ABCG8). SBSO supplementation also increased the production of intestinal short-chain fatty acids and fecal outputs of neutral sterols. Metagenomic analysis demonstrated that feeding SL and SH diets could favorably modulate the relative abundance of Bacteroidales_S24-7_group, Ruminococcaceae, and Eubacteriaceae. It was therefore concluded that SBSO was effective in reducing blood cholesterol in hypercholesterolemic hamsters via increasing intestinal cholesterol excretion and promoting the growth of SCFA-producing bacteria.