Antimicrobial effects of black rice extract on Helicobacter pylori infection in Mongolian gerbil. (January 2019)

• Record Type: Journal Article
• Authors: Kim, Sa-Hyun; Woo, Hyun Jun; Lee, Min Ho; Park, Min; Nagendran, Tharmalingam; Rhee, Ki-Jong; Lee, Dongsup; Jin, Yeung-Bae; Choi, Sik-Won; Seo, Woo Duck; Kim, Jong Bae
• Is Part Of: Journal of cereal science. Volume 85(2019)
• Page Start: 1
• Page End: 5
• Publication Date: 2019-01
• Subjects: Anthocyanin -- Black rice -- Cyanidin 3-O-Glucoside -- Helicobacter pylori; BRE black rice extract -- CagA cytotoxin associated protein A -- C3G cyanidin 3-O-glucoside -- DAB diaminobenzidine -- FFPE formalin-fixed paraffin-embedded -- H&E hematoxylin & eosin -- IHC immunohistochemistry -- RT-qPCR quantitative real-time polymerase chain reaction -- SecA secretion system subunit protein A -- T4SS type IV secretion systems -- T5aSS type Va secretion system -- UPLC ultraperformance liquid chromatography -- VacA vacuolating cytotoxin A; Grain -- Periodicals; Cereal products -- Periodicals; Céréales -- Périodiques; Produits céréaliers -- Périodiques; Cereal products; Grain; Periodicals; 664.705
• DOI: 10.1016/j.jcs.2018.11.002
• Languages: English
• ISSNs: 0733-5210

Abstract

Abstract: It has been reported that cyanidin 3-O-glucoside (C3G) is an inhibitor of Helicobacter pylori toxin secretion. C3G is classified as an anthocyanin and is a major component of black rice extract (BRE). The present study aimed to identify a new functional food material to prevent H. pylori infection in Mongolian gerbil model. Toxicity in the liver and kidney were not detected after BRE administration (10 or 50 mg/kg). BRE treatment reduced bacterial colonization in animal gastric tissue, as well as infection signs as observed on the analysis of the hematological data. It was also found that the relative mRNA levels of the inflammatory cytokines were reduced in BRE-treated groups. These findings suggest that BRE acts as a potent inhibitor of H. pylori infection and pathogenesis in Mongolian gerbils. We propose that BRE may be used to manage gastroduodenal diseases caused by H. pylori infection. Graphical abstract: Image Highlights: Black rice extract (BRE) has no hepatotoxicity and nephrotoxicity. BRE reduced the colonization of H. pylori in Mongolian gerbils. BRE treatment showed anti-inflammatory effect in H. pylori -infected Mongolian gerbils.