The relationship between biological and psychosocial risk factors and resting‐state functional connectivity in 2‐month‐old Bangladeshi infants: A feasibility and pilot study. Issue 5 (29th May 2019)

• Record Type: Journal Article
• Authors: Turesky, Ted K.; Jensen, Sarah K.G.; Yu, Xi; Kumar, Swapna; Wang, Yingying; Sliva, Danielle D.; Gagoski, Borjan; Sanfilippo, Joseph; Zöllei, Lilla; Boyd, Emma; Haque, Rashidul; Hafiz Kakon, Shahria; Islam, Nazrul; Petri, William A.; Nelson, Charles A.; Gaab, Nadine
• Other Names: Jensen Sarah K. G. guestEditor.; Obradović Jelena guestEditor.; Nelson Charles A. guestEditor.
• Is Part Of: Developmental science. Volume 22:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-05-29
• Subjects: Developmental psychology -- Periodicals; Psychology, Comparative -- Periodicals; 155
• DOI: 10.1111/desc.12841
• Languages: English
• ISSNs: 1363-755X

Abstract

Abstract: Childhood poverty has been associated with structural and functional alterations in the developing brain. However, poverty does not alter brain development directly, but acts through associated biological or psychosocial risk factors (e.g. malnutrition, family conflict). Yet few studies have investigated risk factors in the context of infant neurodevelopment, and none have done so in low‐resource settings such as Bangladesh, where children are exposed to multiple, severe biological and psychosocial hazards. In this feasibility and pilot study, usable resting‐state fMRI data were acquired in infants from extremely poor ( n = 16) and (relatively) more affluent ( n = 16) families in Dhaka, Bangladesh. Whole‐brain intrinsic functional connectivity (iFC) was estimated using bilateral seeds in the amygdala, where iFC has shown susceptibility to early life stress, and in sensory areas, which have exhibited less susceptibility to early life hazards. Biological and psychosocial risk factors were examined for associations with iFC. Three resting‐state networks were identified in within‐group brain maps: medial temporal/striatal, visual, and auditory networks. Infants from extremely poor families compared with those from more affluent families exhibited greater (i.e. less negative) iFC in precuneus for amygdala seeds; however, no group differences in iFC were observed for sensory area seeds. Height‐for‐age, a proxy for malnutrition/infection, was not associated with amygdala/precuneus iFC, whereas prenatal family conflict was positively correlated. Findings suggest that it is feasible to conduct infant fMRI studies in low‐resource settings. Challenges and practical steps for successful implementations are discussed. Abstract : Resting‐state fMRI was conducted in a pilot sample of 2‐month‐old infants growing up in urban Bangladesh. Infants from families living in extreme poverty exhibited greater (i.e. less negative) intrinsic functional connectivity (iFC) between amygdala and precuneus compared with infants from more affluent families. Additionally, amygdala/precuneus iFC correlated positively with prenatal family conflict (not shown). As discussed in the report, numerous challenges needed to be overcome to execute this study successfully.