High resolution-ion mobility mass spectrometry as an additional powerful tool for structural characterization of mycotoxin metabolites. (15th April 2018)

• Record Type: Journal Article
• Authors: Righetti, Laura; Fenclova, Marie; Dellafiora, Luca; Hajslova, Jana; Stranska-Zachariasova, Milena; Dall'Asta, Chiara
• Is Part Of: Food chemistry. Volume 245(2018)
• Page Start: 768
• Page End: 774
• Publication Date: 2018-04-15
• Subjects: Alternariol (PubChem CID5359485) -- Alternariol monomethyl ether (PubChem CID5360741) -- Deoxynivalenol (PubChem CID40024) -- Zearalenone (PubChem CID5281576) -- Deoxynivalenol 3-glucuronide (PubChem CID102202100) -- Deoxynivalenol 15-glucuronide (PubChem CID102202102) -- Zearalenone 14-glucuronide (PubChem CID71753018); Modified mycotoxins -- Drift-time ion mobility mass spectrometry -- Metabolite structural characterization; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2017.11.113
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: IM-MS supports the structural identification of isomeric mycotoxin glucuronides. Good correlation between experimental and theoretical CCS was found. The inclusion of CCS values in the annotation procedure is encouraged. Abstract: This work was designed as a proof of concept, to demonstrate the successful use of the comparison between theoretical and experimental collision cross section (CCS) values to support the identification of isomeric forms. To this purpose, thirteen mycotoxins were considered and analyzed using drift time ion mobility mass spectrometry. A good linear correlation ( r 2 = 0.962) between theoretical and experimental CCS was found. The average ΔCCS was 3.2%, fully consistent with the acceptability threshold value commonly set at 5%. The agreement between theoretical and experimental CCS obtained for mycotoxin glucuronides suggested the potential of the CCS matching in supporting the annotation procedure.