AlCl3-promoted reaction of cycloalkanones with hydrazones: a convenient direct synthesis of 4, 5, 6, 7-tetrahydro-1H-indazoles and their analogues. Issue 35 (29th August 2019)

• Record Type: Journal Article
• Authors: Laroum, Rima; Berrée, Fabienne; Roisnel, Thierry; Dorcet, Vincent; Carboni, Bertrand; Debache, Abdelmadjid
• Is Part Of: Tetrahedron letters. Volume 60:Issue 35(2019)
• Publication Date: 2019-08-29
• Subjects: Cycloalkanones -- Hydrazones -- Tetrahydroindazoles -- Aluminum chloride; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2019.150988
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Direct synthesis of 2, 3-diaryl-4, 5, 6, 7-tetrahydro-1 H -indazoles and analogues. Pharmacologically active heterocyclic compounds. Commercially available or easily accessible starting materials. Inexpensive Lewis acid as reagent. Abstract: The AlCl3 -promoted reactions of cycloalkanones with hydrazones are described. This approach represents a mild and operationally simple method to access 2, 3-diaryl-4, 5, 6, 7-tetrahydro-1 H -indazoles and their analogues in good to moderate yields.