AlCl3-promoted reaction of cycloalkanones with hydrazones: a convenient direct synthesis of 4, 5, 6, 7-tetrahydro-1H-indazoles and their analogues. Issue 35 (29th August 2019) - Laroum, Rima
Graphical abstract: Highlights: Direct synthesis of 2, 3-diaryl-4, 5, 6, 7-tetrahydro-1 H -indazoles and analogues. Pharmacologically active heterocyclic compounds. Commercially available or easily accessible starting materials. Inexpensive Lewis acid as reagent. Abstract: The AlCl3 -promoted reactions of cycloalkanones with hydrazones are described. This approach represents a mild and operationally simple method to access 2, 3-diaryl-4, 5, 6, 7-tetrahydro-1 H -indazoles and their analogues in good to moderate yields.