Protective effects of trans-2, 3, 5, 4′-tetrahydroxystilbene 2-O-β-d-glucopyranoside on liver fibrosis and renal injury induced by CCl4via down-regulating p-ERK1/2 and p-Smad1/2. Issue 8 (31st July 2019)

• Record Type: Journal Article
• Authors: Long, Tao; Wang, Liwen; Yang, Yiwen; Yuan, Li; Zhao, Hui; Chang, Chia-Che; Yang, Guliang; Ho, Chi-Tang; Li, Shiming
• Is Part Of: Food & function. Volume 10:Issue 8(2019)
• Page Start: 5115
• Page End: 5123
• Publication Date: 2019-07-31
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c9fo01010f
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Both as a food and an herbal plant, Polygonum multiflorum (PM) has long been used in food and prescriptions for several centuries in Southeast Asia. Abstract : Both as a food and an herbal plant, Polygonum multiflorum (PM) has long been used in food and prescriptions for several centuries in Southeast Asia. trans -2, 3, 5, 4′-tetrahydroxystilbene 2- O -β-d -glucopyranoside ( trans -THSG) is one of the major compounds derived from PM and has been reported to exhibit multiple biological activities such as antioxidation and anti-obesity activities among others. The current study was aimed at investigating the effects of trans -THSG on liver fibrosis and renal injury in a carbon tetrachloride (CCl4 ) induced rodent model via oral feeding. Research results have demonstrated that administration of trans -THSG (100 and 300 mg kg −1 ) significantly ameliorated liver fibrosis, manifested by reduced expression of desmin and α-smooth muscle actin (α-SMA) plus collagen deposition. Specifically, treatment with trans -THSG effectively decreased the levels of transforming growth factor-β (TGF-β) and reduced the phosphorylation of Smad1/2 (p-Smad1/2) and extracellular signal-regulated kinases 1/2 (p-ERK1/2). Furthermore, we found that trans -THSG significantly down-regulated CCl4 -induced excessive collagen secretion and increased the levels of desmin, MMP2 and MMP9 in rat liver tissues, suggesting that trans -THSG prevents liver fibrosis by attenuating the activation of hepatic stellate cells (HSCs) through the inhibition of Smad and ERK signaling pathways. Hence, the present findings demonstrate that trans -THSG is an effective antifibrotic agent in protecting liver from CCl4 -induced toxicity.