Enriched bovine IgG fraction prevents infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium. Issue 8 (17th July 2019)

• Record Type: Journal Article
• Authors: Funatogawa, Keiji; Tada, Tatsuya; Kuwahara‐Arai, Kyoko; Kirikae, Teruo; Takahashi, Masao
• Is Part Of: Food science & nutrition. Volume 7:Issue 8(2019)
• Page Start: 2726
• Page End: 2730
• Publication Date: 2019-07-17
• Subjects: bovine IgG‐enriched whey fraction -- Enterohaemorrhagic Escherichia coli O157:H7 -- Mycobacterium avium -- Salmonella enterica serovar Enteritidis; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.1134
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: A bovine IgG‐enriched whey fraction contains antibodies against various bacterial antigens. We investigated the protective effects of a bovine whey fraction preparation against infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium in mouse models. After infection with these pathogens, the IgG‐enriched fraction or skim milk was given ad libitum at a 5% solution instead of water. The mice given the IgG‐enriched fraction were significantly resistant to orally challenged EHEC O157:H7 (LD50 : 4.0 × 10 5 CFU/mouse) infections compared with the mice given skim milk (LD50 : <1.5 × 10 2 CFU/mouse). The mice given the IgG‐enriched fraction were also significantly resistant to orally challenged S. Enteritidis (LD50 : 5.0 × 10 6 CFU/mouse) infections compared with the mice given skim milk (LD50 : <2.5 × 10 1 CFU/mouse). When the mice were nasally infected with M. avium, the numbers of the bacteria in lungs of mice given the IgG‐enriched fraction were significantly lower than those given skim milk 2 and 3 weeks after infection. These results strongly indicate that oral administration of the bovine IgG‐enriched whey fraction protects mice against food‐borne infection and also that it partially protects mice against respiratory tract infection. Abstract : Oral administration of a bovine IgG‐enriched whey fraction protects mice against food‐borne infections with Enterohaemorrhagic Escherichia coli O157:H7, Salmonella enterica serovar Enteritidis, and Mycobacterium avium, and it partially protects mice against respiratory tract infection.