Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents. Issue 20 (1st November 2018)

• Record Type: Journal Article
• Authors: Xu, Ting; Wang, Xiaoguang; Zhang, Qian; Fan, Jiangping; Liu, Liu; Liu, Mingzhu; Zhang, Haojie; Li, Jing; Guo, Yong
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 28:Issue 20(2018)
• Page Start: 3376
• Page End: 3380
• Publication Date: 2018-11-01
• Subjects: 8-Hydroxyquinaldine -- N–Phenylpyrazole -- Structural modification -- Pesticidal activities -- Structure–activity relationship; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2018.08.041
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Highlights: New N -phenylpyrazole-containing 8-hydroxyquinaldine derivatives were prepared. An efficient way for one pot synthesis of the target compounds was developed. Compounds8g and9f exhibited potent pesticidal activities. The structure-activity relationships were also discussed. Abstract: In continuation of our research aimed at discovery and development of new pesticidal agents, a series of new 8-hydroxyquinaldine derivatives containing a N –phenylpyrazole moiety were prepared and their structures were characterized by 1 H NMR, IR, ESI-MS and mp. Meanwhile, an efficient way of using iodine-mediated oxidative cyclization for one pot synthesis of these 8-hydroxyquinaldine derivatives containing a N –phenylpyrazole moiety was developed. The bioassay showed that compounds8g and9f exhibited potent pesticidal activities against both Mythimna separata Walker and Plutella xylostella Linnaeus. The structure–activity relationships were also discussed.