Iodine-mediated oxidative cyclization for one pot synthesis of new 8-hydroxyquinaldine derivatives containing a N-phenylpyrazole moiety as pesticidal agents. Issue 20 (1st November 2018) - Xu, Ting
Graphical abstract: Highlights: New N -phenylpyrazole-containing 8-hydroxyquinaldine derivatives were prepared. An efficient way for one pot synthesis of the target compounds was developed. Compounds8g and9f exhibited potent pesticidal activities. The structure-activity relationships were also discussed. Abstract: In continuation of our research aimed at discovery and development of new pesticidal agents, a series of new 8-hydroxyquinaldine derivatives containing a N –phenylpyrazole moiety were prepared and their structures were characterized by 1 H NMR, IR, ESI-MS and mp. Meanwhile, an efficient way of using iodine-mediated oxidative cyclization for one pot synthesis of these 8-hydroxyquinaldine derivatives containing a N –phenylpyrazole moiety was developed. The bioassay showed that compounds8g and9f exhibited potent pesticidal activities against both Mythimna separata Walker and Plutella xylostella Linnaeus. The structure–activity relationships were also discussed.