Ameliorative effect of Lactobacillus plantarum WW-fermented soy extract on rat fatty liver via the PPAR signaling pathway. (September 2019)

• Record Type: Journal Article
• Authors: Cao, Chengxu; Wu, Rina; Zhu, Xinyuan; Li, Yang; Li, Mo; An, Feiyu; Wu, Junrui
• Is Part Of: Journal of functional foods. Volume 60(2019)
• Publication Date: 2019-09
• Subjects: Sprague-Dawley rat -- Liver injury -- Transcriptional regulation -- Lipid metabolism; C Control -- L. plantarum WW Lactobacillus plantarum WW -- DEGs differentially expressed genes -- HFD high fat diet -- FSE L. plantarum WW-fermented soymilk soy extract -- CVDs cardiovascular diseases -- NAFLD nonalcoholic fatty liver disease -- SD Sprague-Dawley -- LDL-C low-density lipoprotein cholesterol -- HDL-C high-density lipoprotein cholesterol -- AST aspartate aminotransferase -- ALT alanine aminotransferase -- TC total cholesterol -- TG triglyceride -- MDA serum malondialdehyde -- TBA total bile acid -- GO gene Ontology -- KEEG Kyoto Encyclopedia of Genes and Genomes -- qRT-PCR quantitative reverse transcription-polymerase chain reaction -- PPAR peroxisome proliferator-activated receptors -- CYP7A1 cholesterol 7-alpha hydroxy-lase -- FADS2 fatty acid desaturase 2 -- SCD stearoyl-coenzyme desaturase -- PGAR gamma angio- poietin-related; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2019.103439
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Lactobacillus plantarum WW fermented-soy-extract (FSE) attenuated high-fat-diet (HFD)-induced lipid metabolism dysfunction. We demonstrate liver transcriptome profiles in HFD and HFD + FSE. In this study, we focused on pathways related to lipid signaling. Our observations improve understanding of the mechanisms by which FSE relieves hyperlipidemia. Abstract: The effects of soy extract fermented by Lactobacillus plantarum WW ( L. plantarum WW) on high fat diet (HFD)-induced hyperlipidemia and liver injury were examined. Sprague-Dawley rats were randomly divided into normal chow (C), HFD and HFD + L. plantarum WW-fermented soy extract (HFD + FSE). We found that L. plantarum WW-FSE treatment significantly restored changes to body weight and pathological indices caused by fatty liver disease. RNA-seq analysis showed that treatment with L. plantarum WW-FSE altered expression of genes involved in lipid metabolism, and in oxidation-reduction processes. This study supported that the peroxisome proliferator-activated receptor (PPAR) signaling pathway may be involved in lipid metabolism, and suggested that dietary L. plantarum WW-FSE ameliorates HFD-induced lipid metabolism disturbance in rat liver associated with PPAR signaling pathway. These observations shed new light on possible treatment of hyperlipidemia.