Phenolic constituents with neuroprotective activities from Hypericum wightianum. (September 2019)

• Record Type: Journal Article
• Authors: Yang, Ling; Wang, Zi-Ming; Wang, Yun; Li, Rong-Sheng; Wang, Fei; Wang, Kou
• Is Part Of: Phytochemistry. Volume 165(2019)
• Publication Date: 2019-09
• Subjects: Hypericum wightianum wall. ex wight et Arn. -- Hypericaceae -- Depsidone -- Flavone derivative -- Benzophenone glycosides -- Neuroprotective activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2019.112049
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum . Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM. Graphical abstract: Image 108 Highlights: Five undescribed phenolic constituents were isolated from the whole plant of Hypericum wightianum. Three compounds exhibited noticeable neuroprotection against corticosterone-induced PC12 cell injury. Hyperwightin A represents the second report of depsidones in the genus Hypericum.