Phenolic constituents with neuroprotective activities from Hypericum wightianum. (September 2019) - Yang, Ling
Abstract: Five undescribed phenolic compounds, inclusing a depsidone derivative, hyperwightin A, a flavone derivative, hyperwightin B, and three benzophenone glycosides, hyperwightins C-E, along with four known ones were isolated from the 95% EtOH extract of the whole plants of Hypericum wightianum . Structures of the obtained compounds were elucidated by spectroscopic analyses. The protective effects of the isolates against corticosterone-induced PC12 cell injury were assessed. Hyperwightin E, petiolin G and hyperxanthone exhibited noticeable neuroprotection at 10 μM. Graphical abstract: Image 108 Highlights: Five undescribed phenolic constituents were isolated from the whole plant of Hypericum wightianum. Three compounds exhibited noticeable neuroprotection against corticosterone-induced PC12 cell injury. Hyperwightin A represents the second report of depsidones in the genus Hypericum.