Adverse Effects of Grape Seed Extract Supplement: A Clinical Case and Long-Term Follow-Up. (3rd March 2016)

• Record Type: Journal Article
• Authors: Berry, Andrew C.; Nakshabendi, Rahman; Abidali, Hussein; Atchaneeyasakul, Kunakorn; Dholaria, Kevin; Johnson, Cassandra; Kishore, Varsha A.; Baltz, Aaron C.
• Is Part Of: Journal of dietary supplements. Volume 13:Number 2(2016:Jun.)
• Page Start: 232
• Page End: 235
• Publication Date: 2016-03-03
• Subjects: chemopreventive -- grape seed extract -- nutrition -- supplements; Dietary supplements -- Periodicals; Dietary Supplements -- Periodicals; 613.205
• DOI: 10.3109/19390211.2015.1008617
• Languages: English
• ISSNs: 1939-0211

Abstract

ABSTRACT : Grape seed extract (GSE) supplement use is becoming more popular today for its potential chemopreventive and chemotherapeutic role. We report a 49-year-old male who presented with recurrent nausea, vomiting, diarrhea, and acute weakness following GSE use. A thorough medical workup ensued and no causes were identified clinically, procedurally, or with imaging. Symptoms resolved after GSE discontinuation and the patient remained symptom-free 5 years later. This case illustrates the paucity of documented detailed clinical cases and lack of controlled trials detailing a thorough and reproducible adverse effect profile of GSE supplement.