The effect of dietary soy intake on weight loss, glycaemic control, lipid profiles and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome: a randomised clinical trial. Issue 4 (22nd February 2018)

• Record Type: Journal Article
• Authors: Karamali, M.; Kashanian, M.; Alaeinasab, S.; Asemi, Z.
• Is Part Of: Journal of human nutrition and dietetics. Volume 31:Issue 4(2018)
• Page Start: 533
• Page End: 543
• Publication Date: 2018-02-22
• Subjects: soy diet -- weight loss -- metabolic status -- polycystic ovary syndrome; Dietetics -- Periodicals; Nutrition -- Periodicals; 613.205
• DOI: 10.1111/jhn.12545
• Languages: English
• ISSNs: 0952-3871

Abstract

Abstract: Background: The present study aimed to evaluate the effects of dietary soy intake on weight loss and metabolic status of patients with polycystic ovary syndrome (PCOS). Methods: A randomised clinical trial was conducted among 60 women with PCOS. Participants were randomly assigned into two groups to receive either a test diet ( n = 30) or a control diet ( n = 30) for 8 weeks. Participants in the test group consumed a diet containing 0.8 g protein kg –1 body weight (35% animal proteins, 35% soy protein and 30% vegetable proteins) and participants in the control group consumed a similar diet containing 70% animal proteins and 30% vegetable proteins. Results: Adherence to the test diet, compared with the control diet, resulted in significant decreases [mean (SD)] in body mass index (BMI) [−0.3 (0.6) versus +0.1 (0.5) kg m –2, P = 0.02], fasting plasma glucose [−0.2 (0.5) versus +0.1 (0.3) mmol L −1, P = 0.01], total testosterone [−0.3 (0.7) versus +0.3 (0.3) mmol L −1, P < 0.001], insulin [−15.0 (18.0) versus +4.8 (18.6) pmol L −1, P < 0.001] and insulin resistance [−0.6 (0.6) versus +0.2 (0.7), P < 0.001], as well as a significant increase in quantitative insulin sensitivity check index [+0.01 (0.01) versus −0.002 (0.02), P = 0.01]. In addition, significant decreases in triglycerides [−0.1 (0.4) versus +0.2 (0.3) mmol L −1, P = 0.01] and malondialdehyde (MDA) [−1.2 (1.0) versus +0.2 (1.2) μmol L −1, P < 0.001] and significant increases in nitric oxide (NO) [+13.6 (14.1) versus +0.9 (24.3) μmol L −1, P = 0.01] and glutathione (GSH) [+170.1 (175.5) versus +24.2 (168.7) μmol L −1, P = 0.002] were seen in the test group compared to the control. Conclusions: Adherence to test diet among subjects with PCOS significantly decreased BMI, glycaemic control, total testosterone, triglycerides and MDA, and significantly increased NO and GSH compared to the control diet.