Disentangling serology to elucidate henipa‐ and filovirus transmission in Madagascar fruit bats. Issue 7 (15th April 2019)

• Record Type: Journal Article
• Authors: Brook, Cara E.; Ranaivoson, Hafaliana C.; Broder, Christopher C.; Cunningham, Andrew A.; Héraud, Jean‐Michel; Peel, Alison J.; Gibson, Louise; Wood, James L. N.; Metcalf, C. Jessica; Dobson, Andrew P.
• Editors: Fenton, Andy
• Is Part Of: Journal of animal ecology. Volume 88:Issue 7(2019)
• Page Start: 1001
• Page End: 1016
• Publication Date: 2019-04-15
• Subjects: age–seroprevalence -- filovirus -- flying fox -- force of infection -- fruit bat -- henipavirus -- Madagascar -- zoonosis; Animal ecology -- Periodicals; 591.7
• DOI: 10.1111/1365-2656.12985
• Languages: English
• ISSNs: 0021-8790

Abstract

Abstract: Bats are reservoirs for emerging human pathogens, including Hendra and Nipah henipaviruses and Ebola and Marburg filoviruses. These viruses demonstrate predictable patterns in seasonality and age structure across multiple systems; previous work suggests that they may circulate in Madagascar's endemic fruit bats, which are widely consumed as human food. We aimed to (a) document the extent of henipa‐ and filovirus exposure among Malagasy fruit bats, (b) explore seasonality in seroprevalence and serostatus in these bat populations and (c) compare mechanistic hypotheses for possible transmission dynamics underlying these data. To this end, we amassed and analysed a unique dataset documenting longitudinal serological henipa‐ and filovirus dynamics in three Madagascar fruit bat species. We uncovered serological evidence of exposure to Hendra‐/Nipah‐related henipaviruses in Eidolon dupreanum, Pteropus rufus and Rousettus madagascariensis, to Cedar‐related henipaviruses in E. dupreanum and R. madagascariensis and to Ebola‐related filoviruses in P. rufus and R. madagascariensis . We demonstrated significant seasonality in population‐level seroprevalence and individual serostatus for multiple viruses across these species, linked to the female reproductive calendar. An age‐structured subset of the data highlighted evidence of waning maternal antibodies in neonates, increasing seroprevalence in young and decreasing seroprevalence late in life. Comparison of mechanistic epidemiological models fit to these data offered support for transmission hypotheses permitting waning antibodies but retained immunity in adult‐age bats. Our findings suggest that bats may seasonally modulate mechanisms of pathogen control, with consequences for population‐level transmission. Additionally, we narrow the field of candidate transmission hypotheses by which bats are presumed to host and transmit potentially zoonotic viruses globally. Abstract : In this paper, the authors (a) expand globally on the known range of bat hosts for henipaviruses and filoviruses, (b) demonstrate seasonal patterns in population‐level seroprevalence and individual‐level serostatus for Malagasy fruit bats and (c) use mechanistic models to reveal the critical role of waning humoral immunity in serological dynamics.