Essential oil components and cytochrome P450 enzymes: a review. (5th April 2019)

• Record Type: Journal Article
• Authors: Zehetner, Petra; Höferl, Martina; Buchbauer, Gerhard
• Is Part Of: Flavour and fragrance journal. Volume 34:Number 4(2019:Jul.)
• Page Start: 223
• Page End: 240
• Publication Date: 2019-04-05
• Subjects: biotransformation of xenobiotics -- CYP induction -- CYP inhibition -- cytochrome P450 -- essential oil constituents -- metabolism; Flavor -- Periodicals; Odors -- Periodicals; Smell -- Periodicals; 668.54
• DOI: 10.1002/ffj.3496
• Languages: English
• ISSNs: 0882-5734

Abstract

Abstract: Phase‐I metabolism mediated by cytochrome P450 (CYP) enzymes represents a major route of elimination of many drugs that can compete for the same CYP enzyme. The bioactivity of essential oils (EOs) and their flavour and fragrance constituents have been known since ancient times, and like any other physiological process in the human body the activity of CYP enzymes can also be influenced (increased and/or decreased) by these natural compounds. This review discusses the effects of EO constituents on important drug‐metabolizing CYP enzymes. Exposure to EO constituents through commonly used products via cutaneous, oral, and inhalation routes is outlined, and the impact of some important EO constituents on CYP enzymes is described in more detail. In particular, the simultaneous application of EO constituents with drugs or the excessive use of EOs and their constituents can lead to unexpected adverse effects. Abstract : Influence of Cytochrome P450 on the Metabolism of an Essential Oil Constituent.