Yacon flour (Smallanthus sonchifolius) attenuates intestinal morbidity in rats with colon cancer. (October 2017)

• Record Type: Journal Article
• Authors: Grancieri, Mariana; Costa, Neuza Maria Brunoro; Vaz Tostes, Maria das Graças; de Oliveira, Daniela Silva; Nunes, Louisiane de Carvalho; Marcon, Letícia de Nadai; Veridiano, Thaísa Agrizzi; Viana, Mirelle Lomar
• Is Part Of: Journal of functional foods. Volume 37(2017)
• Page Start: 666
• Page End: 675
• Publication Date: 2017-10
• Subjects: YF yacon flour -- CRC colorectal câncer -- FOS fructooligosaccharides -- SCFA short-chain fatty acids -- ACF aberrant crypts focus; Fructooligosaccharides -- Prebiotics -- Intestinal permeability -- SCFA -- pH; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2017.08.039
• Languages: English
• ISSNs: 1756-4646

Abstract

Highlights: Evaluate the yacon flour effect on intestinal health in rats with colorectal cancer. Yacon flour reduces intestinal permeability in rats with colorectal cancer. Yacon flour reduces the percentage of aberrant crypt foci in rats with colorectal cancer. Yacon flour increases the depth and number of crypts colonic. Yacon flour reduces pH and increased formation of short chain fatty acids. Abstract: Yacon flour (YF) ( Smallanthus sonchifolius ) is source of fructooligosaccharides (FOS) which are prebiotic with effects unknown in the colorectal cancer (CRC). This study investigated the intestinal effects of supplementation with 7.5% FOS from YF for 8 weeks on CRC induced by 1.2-dimethylhydrazine (25 mg/kg/body weight) in male Wistar rats. The animals were divided in groups: S (without YF and without induced CRC, n = 10), Y (with YF and without induced CRC, n = 10), C (without YF and with induced CRC, n = 10) and CY (with YF and with induced CRC, n = 10). The animals that received YF had a percentage reduction of aberrant crypts focus in more than 40%, lower intestinal permeability, luminal content more acidic and with higher concentrations of SCFA. In addition, there was an increase in the depth and number of colonic crypts. In conclusion, we observed that YF promoted beneficial effects on the intestinal health of animals with induced CRC.