Cyanidin‐3‐glucoside increases whole body energy metabolism by upregulating brown adipose tissue mitochondrial function. Issue 11 (28th August 2017)

• Record Type: Journal Article
• Authors: You, Yilin; Yuan, Xiaoxue; Liu, Xiaomeng; Liang, Chen; Meng, Minghui; Huang, Yuanyuan; Han, Xue; Guo, Jielong; Guo, Yu; Ren, Chenglong; Zhang, Qianwen; Sun, Xiangyu; Ma, Tingting; Liu, Guojie; Jin, Wanzhu; Huang, Weidong; Zhan, Jicheng
• Is Part Of: Molecular nutrition & food research. Volume 61:Issue 11(2017)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-08-28
• Subjects: Brown adipose tissue -- Cyanidin‐3‐glucoside -- Energy metabolism -- Mitochondrial function -- Obesity; Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201700261
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Scope: Obesity develops when energy intake exceeds energy expenditure. Promoting brown adipose tissue (BAT) formation and function increases energy expenditure and may protect against obesity. Cyanidin‐3‐glucoside (C3G) is an anthocyanin compound that occurs naturally in many fruits and vegetables. In this study, we investigated the effect and mechanism of C3G on the prevention of obesity. Methods and results: Db/db mice received C3G dissolved in drinking water for 16 wk; drinking water served as the vehicle treatment. The total body weight, energy intake, metabolic rate, and physical activity were measured. The lipid droplets, gene expression and protein expression were evaluated by histochemical staining, real‐time PCR, and western blots. We found that C3G increased energy expenditure, limited weight gain, maintained glucose homeostasis, reversed hepatic steatosis, improved cold tolerance, and enhanced BAT activity in obese db/db mice. C3G also induces brown‐like adipocytes (beige) formation in subcutaneous white adipose tissue (sWAT) of db/db mice model. We also found that C3G potently regulates the transcription of uncoupling protein 1 (UCP1) both in BAT and sWAT through increasing mitochondrial number and function. Conclusion: Our results suggest that C3G plays a role in regulating systemic energy balance, which may have potential therapeutic implications for the prevention and control of obesity. Abstract : Cyanidin‐3‐glucoside (C3G) activates SIRT1, then enhances PGC1‐α activity, upregulates TFAM transcriptional activity, and increases mitochondrial biogenesis and function resulting in increased BAT activity and beige formation, and then resisted obesity and diabetes.