Two new terpenoid ester glycosides from the twigs of Litsea cubeba. Issue 12 (2nd December 2018)

• Record Type: Journal Article
• Authors: Wang, Ling-Yan; Tian, Ye; Qu, Yu-Hong; Wu, Yu-Zhuo; Li, Yan-Cheng; Li, Rui; Lin, Peng-Cheng; Shang, Xiao-Ya; Lin, Sheng
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 12(2018)
• Page Start: 1129
• Page End: 1136
• Publication Date: 2018-12-02
• Subjects: Lauraceae -- Litsea cubeba -- sesquiterpenoid ester glycoside -- monoterpenoid ester glycoside -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1526789
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new sesquiterpenoid ester glycoside (1 ) and a new monoterpenoid ester glycoside (2 ) have been isolated from an ethanol extract of the twigs of Litsea cubeba . Their structures were elucidated by extensive 1D- and 2D-NMR experiments, and the absolute configurations were determined by chemical methods, specific rotation, and a combination of experimental and theoretically calculated electronic circular dichroism spectra. Compound1 exhibited selective cytotoxicity against A549 and HCT-8 cell lines with the IC50 values of 8.9 and 9.6 μ M, respectively.