Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors. (28th July 2011)

• Record Type: Journal Article
• Authors: Idahl, Annika; Lundin, Eva; Jurstrand, Margaretha; Kumlin, Urban; Elgh, Fredrik; Ohlson, Nina; Ottander, Ulrika
• Other Names: Spear Gregory T. Academic Editor.
• Is Part Of: Infectious diseases in obstetrics and gynecology. Volume 2011(2011)
• Publication Date: 2011-07-28
• Subjects: Generative organs, Female -- Infections -- Periodicals; Communicable diseases in pregnancy -- Periodicals; 618.142005
• DOI: 10.1155/2011/824627
• Languages: English
• ISSNs: 1064-7449

Abstract

Abstract : Objective . To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods . Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n = 12 ), ovarian carcinoma (n = 45 ), or other pelvic malignancies (n = 11 ) were matched to four healthy controls each. Results . Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P = .002 ) in women with plasma samples obtained >1 year prior to diagnosis (n = 7 ). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P = .01 ). Conclusion . Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.