Chlamydia trachomatis and Mycoplasma genitalium Plasma Antibodies in Relation to Epithelial Ovarian Tumors. (28th July 2011) - Idahl, Annika
Abstract : Objective . To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors. Methods . Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n = 12 ), ovarian carcinoma (n = 45 ), or other pelvic malignancies (n = 11 ) were matched to four healthy controls each. Results . Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P = .002 ) in women with plasma samples obtained >1 year prior to diagnosis (n = 7 ). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P = .01 ). Conclusion . Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.