Donor Small-Droplet Macrovesicular Steatosis Affects Liver Transplant Outcome in HCV-Negative Recipients. (2nd May 2019)

• Record Type: Journal Article
• Authors: Ferri, Flaminia; Lai, Quirino; Molinaro, Antonio; Poli, Edoardo; Parlati, Lucia; Lattanzi, Barbara; Mennini, Gianluca; Melandro, Fabio; Pugliese, Francesco; Maldarelli, Federica; Corsi, Alessandro; Riminucci, Mara; Merli, Manuela; Rossi, Massimo; Ginanni Corradini, Stefano
• Other Names: Peltekian Kevork M. Academic Editor.
• Is Part Of: Canadian journal of gastroenterology & hepatology. Volume 2019(2019)
• Publication Date: 2019-05-02
• Subjects: Digestive organs -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Digestive organs -- Diseases; Gastroenterology; Canada; Digestive System Diseases -- Periodicals; Gastroenterology -- Periodicals; Periodicals; Electronic journals; Fulltext; Internet Resources; Periodicals; 616.3
• DOI: 10.1155/2019/5862985
• Languages: English
• ISSNs: 2291-2789

Abstract

Abstract : Background . No data are available on liver transplantation (LT) outcome and donor liver steatosis, classified as large droplet macrovesicular (Ld-MaS), small-droplet macrovesicular (Sd-MaS), and true microvesicular (MiS), taking into account the recipient Hepatitis C virus (HCV) status. Aim . We investigate the impact of allograft steatosis reclassified according to the Brunt classification on early graft function and survival after LT. Methods . We retrospectively reviewed 204 consecutive preischemia biopsies of grafts transplanted in our center during the period 2001-2011 according to recipient HCV status. Results . The median follow-up after LT was 7.5 years (range: 0.0-16.7). In negative recipients (n=122), graft loss was independently associated with graft Sd-MaS, in multivariable Cox regression models comprehending only pre-/intraoperative variables (HR=1.03, 95%CI=1.01-1.05; P =0.003) and when including indexes of early postoperative graft function (HR=1.04, 95%CI=1.02-1.06; P =0.001). Graft Sd-MaS>15% showed a risk for graft loss > 2.5-folds in both the models. Graft Sd-MaS>15% was associated with reduced graft ATP content and, only in HCV- recipients, with higher early post-LT serum AST peaks. Conclusions . In HCV-negative recipients, allografts with >15% Sd-MaS have significantly reduced graft survival and show low ATP and higher AST peaks in the immediate posttransplant period. Donors with >15% Sd-MaS have significantly higher BMI, longer ICU stays, and lower PaO2.