Α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307. Issue 24 (17th December 2018)

• Record Type: Journal Article
• Authors: Zhang, Liuhong; Niaz, Shah Iram; Wang, Zhen; Zhu, Yonghong; Lin, Yongcheng; Li, Jing; Liu, Lan
• Is Part Of: Natural product research. Volume 32:Issue 24(2018)
• Page Start: 2887
• Page End: 2892
• Publication Date: 2018-12-17
• Subjects: Botryorhodine H -- Trichoderma sp -- endophytic fungus -- α-glucosidase inhibitory activity -- cytotoxicity; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1385023
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: One new depsidone, botryorhodine H (1 ), together with three known analogues, botryorhodines C, D and G (2 –4 ), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds1 –3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM). Abstract :