Α-Glucosidase inhibitory and cytotoxic botryorhodines from mangrove endophytic fungus Trichoderma sp. 307. Issue 24 (17th December 2018) - Zhang, Liuhong
Abstract: One new depsidone, botryorhodine H (1 ), together with three known analogues, botryorhodines C, D and G (2 –4 ), were obtained from the mangrove endophytic fungus Trichoderma sp. 307 by co-culturing with Acinetobacter johnsonii B2. Structures were determined by 1D and 2D NMR analyses and high-resolution mass spectrum. Compounds1 –3 showed α-glucosidase inhibitory activity with IC50 ranging from 8.1 to 11.2 μM, and compound1 exhibited potent cytotoxicity against rat prolactinoma MMQ and rat pituitary adenoma GH3 cell lines (IC50 = 3.09 and 3.64 μM). Abstract :