Phytochemical investigation of Magnolia grandiflora green seed cones: Analytical and phytoceutical studies. Issue 5 (14th April 2019)

• Record Type: Journal Article
• Authors: Garza, Bo; Echeverria, Alondra; Gonzalez, Felipe; Castillo, Orlando; Eubanks, Thomas; Bandyopadhyay, Debasish
• Is Part Of: Food science & nutrition. Volume 7:Issue 5(2019)
• Page Start: 1761
• Page End: 1767
• Publication Date: 2019-04-14
• Subjects: druggability -- gas chromatography‐mass spectroscopy -- Magnolia grandiflora -- phytoceutical -- phytochemical -- X‐ray crystallography; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.1016
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Phytochemicals are inevitable part of human civilization. It is impossible to say exactly when menfolk started to take plant portions to cure various diseases. Phytochemical investigation of diethyl ether and ethanol extracts of Magnolia grandiflora green seed cones has been carried out. Extraction, isolation, and identification of the phytochemicals were carried out. Structures were determined by various analytical methods including extensive nuclear magnetic resonance, gas chromatography‐mass spectroscopy, and X‐ray crystallographic analyses. Structures of the three compounds viz . 5, 5′‐diallyl‐[1, 1′‐biphenyl]‐2, 2′‐diol (I ), 3′, 5‐diallyl‐[1, 1′‐biphenyl]‐2, 4′‐diol (II ), and (3 S, 3 aS, 8 S, 9 aS, 10 aR, 10 bS, E )‐8‐hydroxy‐3, 6, 9 a ‐trimethyl‐3 a, 4, 5, 8, 9, 9 a, 10 a, 10 b ‐octahydrooxireno[2′, 3′:9, 10]cyclodeca[1, 2‐ b ]furan‐2(3 H )‐one (III ) were confirmed by X‐ray crystallographic analysis. GS‐MS studies of the isolated oil, eluted with hexanes, revealed the presence of eight compounds including two highly bio‐privileged molecules 5, 5′‐diallyl‐2′‐methoxy‐[1, 1′‐biphenyl]‐2‐ol (IV ) and 1‐(4‐isopropylbenzyl)‐1, 3‐dihydro‐2 H ‐benzo[ d ]imidazol‐2‐one (V ). The druggability of the five compounds has also been determined by in silico studies. The isolated compounds and/or their semi‐synthetic products may find application in natural drug development research. Abstract : Nature is the major source of numerous bioactive compounds. Along with other molecules, five medicinally privileged molecules have been identified from Magnolia grandiflora green seed cones. These molecules have potential to generate active pharmaceutical ingredients by appropriate chemical modification through functionalization.