Relationship between daily isoflavone intake and sleep in Japanese adults: a cross-sectional study. Issue 1 (December 2015)

• Record Type: Journal Article
• Authors: Cui, Yufei; Niu, Kaijun; Huang, Cong; Momma, Haruki; Guan, Lei; Kobayashi, Yoritoshi; Guo, Hui; Chujo, Masahiko; Otomo, Atsushi; Nagatomi, Ryoichi
• Is Part Of: Nutrition journal. Volume 14:Issue 1(2015)
• Page Start: 1
• Page End: 7
• Publication Date: 2015-12
• Subjects: Cross-sectional study -- Isoflavone -- Sleep duration -- Sleep quality -- Estrogen -- Japanese adults; Nutrition -- Periodicals; 612.305
• DOI: 10.1186/s12937-015-0117-x
• Languages: English
• ISSNs: 1475-2891

Abstract

Abstract Background Isoflavones comprise a class of phytoestrogens that resemble human estrogen in chemical structure, and have weak estrogenic effects. Because estrogen modulates sleep duration and quality, we hypothesized that isoflavones would have a beneficial effect on sleep status in a way similar to estrogen. We conducted a cross-sectional study to investigate the relationship between daily isoflavone intake and sleep status in Japanese subjects. Methods Our study included 1076 Japanese adults aged 20-78 years. Daily isoflavone intake was assessed using a brief self-administered diet history questionnaire, and sleep was evaluated using a self-reported questionnaire. Results The prevalence of regular sleep duration (7–8 h/day) and sufficient sleep quality were 13.3 % and 56.2 %, respectively. After adjusting for potential confounding factors, the odds ratios (95 % CIs) for optimal sleep duration (7–8 h) when higher isoflavone intakes (Q2–Q4) were compared with low isoflavone intake (Q1) were Q2: 0.94 (0.53–1.56); Q3: 1.28 (0.73–2.24); and Q4: 1.84 (1.06–3.18) (p for trend = 0.013). In the final adjusted model, sufficient sleep quality across categories of isoflavone intake was Q1: 1.00 (reference); Q2: 1.30 (0.91–1.84); Q3: 1.48 (1.03–2.12); and Q4: 1.78 (1.22–2.60); (p for trend = 0.002). Conclusion Higher daily isoflavone intake was positively associated with optimal sleep duration and quality in a Japanese population. This finding suggests that daily isoflavone intake may have a potentially beneficial effect on sleep status.