6‐Gingerol, an active pungent component of ginger, inhibits L‐type Ca2+ current, contractility, and Ca2+ transients in isolated rat ventricular myocytes. Issue 4 (19th February 2019)

• Record Type: Journal Article
• Authors: Han, Xue; Zhang, Yuanyuan; Liang, Yingran; Zhang, Jianping; Li, Mengying; Zhao, Zhifeng; Zhang, Xuan; Xue, Yurun; Zhang, Ying; Xiao, Jingkai; Chu, Li
• Is Part Of: Food science & nutrition. Volume 7:Issue 4(2019)
• Page Start: 1344
• Page End: 1352
• Publication Date: 2019-02-19
• Subjects: 6‐Gingerol -- Ca2+ transients -- cardiomyocytes -- contractility -- L‐type Ca2+ current; Food industry and trade -- Periodicals; Food -- Periodicals; Nutrition -- Periodicals; 664
• DOI: 10.1002/fsn3.968
• Languages: English
• ISSNs: 2048-7177

Abstract

Abstract: Ginger has been widely used as a flavor, food, and traditional medicine for centuries. 6‐Gingerol (6‐Gin) is the active components of ginger and offers some beneficial effects on cardiovascular diseases. Here, the effects of 6‐Gin on L‐type Ca 2+ current (ICa‐L ), contractility, and the Ca 2+ transients of rat cardiomyocytes, were investigated via patch‐clamp technique and the Ion Optix system. The 6‐Gin decreased the ICa‐L of normal and ischemic ventricular myocytes by 58.17 ± 1.05% and 55.22 ± 1.34%, respectively. 6‐Gin decreased ICa‐L in a concentration‐dependent manner with a half‐maximal inhibitory concentration (IC50 ) of 31.25 μmol/L. At 300 μmol/L, 6‐Gin reduced the cell shortening by 48.87 ± 5.44% and the transients by 42.5 ± 9.79%. The results indicate that the molecular mechanisms underlying the cardio‐protective effects of 6‐Gin may because of a decreasing of intracellular Ca 2+ via the inhibition of ICa‐L and contractility in rat cardiomyocytes. Abstract : 6‐Gingerol inhibits L‐type Ca2+ current, contractility, and Ca2+ transients in isolated rat ventricular myocytes.