Functionalization of amino terminated carbon nanotubes with isocyanates for magnetic solid phase extraction of sulfonamides from milk and their subsequent determination by liquid chromatography-high resolution mass spectrometry. (15th August 2019)

• Record Type: Journal Article
• Authors: Fu, Lin; Zhou, Hao; Miao, Enming; Lu, Shiwei; Jing, Siyuan; Hu, Yufeng; Wei, Lijuan; Zhan, Jingjing; Wu, Minghuo
• Is Part Of: Food chemistry. Volume 289(2019)
• Page Start: 701
• Page End: 707
• Publication Date: 2019-08-15
• Subjects: Magnetic solid phase extraction -- High resolution mass spectrometry -- Sulfonamides -- Sample preparation -- Carbon nanotubes; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2019.03.097
• Languages: English
• ISSNs: 0308-8146

Abstract

Highlights: Functionalization of amino-terminated carbon nanotubes with isocyanates. Application of functionalized magnetic carbon nanotubes in MSPE. Development of MSPE-LC-HRMS method for sulfonamides analysis. Abstract: A simple modification method was developed for the functionalization of amino terminated carbon nanotubes (CNT-NH2 ) by using isocyanates as modifiers via the nucleophilic addition reaction. Two types of functionalized magnetic carbon nanotubes (MCNT) were prepared through deposition of magnetic nanoparticles on CNT-NH2 and modification with different isocyanates. p-Tolyl-functionalized MCNT (Tol-MCNT) with better adsorption performance were selected as adsorbent for magnetic solid phase extraction (MSPE), which could extract sulfonamides (SAs) from various milk samples with a enrichment factor of about 30 after optimization. By combining the MSPE with liquid chromatography–high resolution mass spectrometry (LC–HRMS), a new method was developed. Both skimmed and whole milk samples of three brands were analyzed with this method, and 4 SAs including sulfadiazine, sulfisomidine, sulfamethazine and sulfameter were detected with the concentration from unquantifiable to 72 ng/L, which were all well below the maximum residue limits in milk according to the regulations of China and EU.