Second generation DNA-encoded dynamic combinatorial chemical libraries. Issue 26 (12th March 2019)

• Record Type: Journal Article
• Authors: Reddavide, Francesco V.; Cui, Meiying; Lin, Weilin; Fu, Naiqiang; Heiden, Stephan; Andrade, Helena; Thompson, Michael; Zhang, Yixin
• Is Part Of: Chemical communications. Volume 55:Issue 26(2019)
• Page Start: 3753
• Page End: 3756
• Publication Date: 2019-03-12
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc01429b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel DNA-encoded chemical library architecture can mimic the mechanisms of immunity to evolve binders through recombination, dynamics and adaption. Abstract : We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries.