Second generation DNA-encoded dynamic combinatorial chemical libraries. Issue 26 (12th March 2019) - Reddavide, Francesco V.
Abstract : A novel DNA-encoded chemical library architecture can mimic the mechanisms of immunity to evolve binders through recombination, dynamics and adaption. Abstract : We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries.