Front cover: Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt‐nNOS Signaling in the Nucleus Tractus Solitarii in Rats. Issue 6 (21st March 2019)

• Record Type: Journal Article
• Authors: Chen, Hsin‐Hung; Yeh, Tung‐Chen; Cheng, Pei‐Wen; Ho, Wen‐Yu; Ho, Chiu‐Yi; Lai, Chi‐Cheng; Sun, Gwo‐Ching; Tseng, Ching‐Jiunn
• Is Part Of: Molecular nutrition & food research. Volume 63:Issue 6(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-03-21
• Subjects: Food -- Biotechnology -- Periodicals; Food -- Microbiology -- Periodicals; Nutrition -- Periodicals; Food -- Toxicology -- Periodicals; Nutrition -- Periodicals; Food Microbiology -- Periodicals; Food Technology -- Periodicals; Molecular Biology -- Periodicals; 664.0705
• DOI: 10.1002/mnfr.201970015
• Languages: English
• ISSNs: 1613-4125

Abstract

Abstract : Mol. Nutr. Food Res . 2019, 63, 1801042 DOI:10.1002/mnfr.201801042 Coenzyme Q10 (CoQ10) has therapeutic benefits for oxidative stress and hypertension. Fructose might mediate this process via the overexpression of superoxide in the nucleus tractus solitarii (NTS), stimulation of NADPH oxidase activation, and the phosphorylation of p‐p38. However, CoQ10 mediates insulin downstream signaling in the NTS by 10% fructose intake via the phosphorylation of Akt S473 and nNOS S1416 and improves neurogenic hypertension via the inhibition of NADPH oxidases and increased SOD2 expression in the NTS.