Anti-neuroinflammatory and antioxidant phenylpropanoids from Chinese olive. (15th July 2019)

• Record Type: Journal Article
• Authors: Zhang, Shujuan; Huang, Yuying; Li, Yang; Wang, Yihai; He, Xiangjiu
• Is Part Of: Food chemistry. Volume 286(2019)
• Page Start: 421
• Page End: 427
• Publication Date: 2019-07-15
• Subjects: COX-2 cyclooxygenase-2 -- DEPT distortionless enhancement by polarization transfer -- DPPH 2, 2-diphenyl-1-picrylhydrazyl -- HMBC heteronuclear multiple-bond correlation -- HPLC high-performance liquid chromatography -- HSQC heteronuclear single quantum coherence -- HR-ESI-Q-TOF-MS high-resolution electrospray ionization quadrupole time-of-flight mass spectrometry -- iNOS inducible nitric oxide synthase -- LPS lipopolysaccharides -- MPLC medium pressure liquid chromatography -- MTT 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide -- NMR nuclear magnetic resonance -- NO nitric oxide -- 1H-1H COSY proton-proton correlation spectroscopy; Chinese olive -- Canarium album L. -- Phenylpropanoids -- Anti-neuroinflammatory -- Antioxidant; Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; 664
• DOI: 10.1016/j.foodchem.2019.02.031
• Languages: English
• ISSNs: 0308-8146

Abstract

Graphical abstract: Highlights: Bioactive phytochemicals of Chinese olive were conducted. Nineteen phenylpropanoids, including three novels, were isolated from Chinese olive. Some phenylpropanoids showed pronounced anti-neuroinflammatory, antioxidant and antidiabetic activities. Chinese olives could be served as a healthy product for neuroinflammatory related diseases. Abstract: Chinese olive is served as a famous fruit and traditional herb in China. In this study, the anti-neuroinflammatory and antioxidant phytochemicals of Chinese olive fruits were investigated. Three new phenylpropanoids (2, 6, 19 ), together with sixteen known congeners, have been isolated and identified. A variety of bioactivities related to the traditional healthy benefits of Chinese olive, including anti-neuroinflammatory, antioxidant and antidiabetic, have been evaluated for the identified compounds. The phenylpropanoids could significantly inhibit the production of nitric oxide induced by lipopolysaccharide (LPS) in microglia cells (BV-2). Compounds2, 6, and19 could dose-dependently reduce the expression levels of pro-inflammatory mediator iNOS and COX-2 expressions induced by LPS in BV-2 cells. Meanwhile, some phenylpropanoids showed remarkable antioxidant and antidiabetic activities. This study suggested that Chinese olive could be served as a healthy product for neuroinflammatory related diseases, such as Alzheimer's disease.