Designing dual-functionalized carbon nanotubes with high blood–brain-barrier permeability for precise orthotopic glioma therapy. Issue 5 (30th November 2018)

• Record Type: Journal Article
• Authors: You, Yuanyuan; Wang, Ni; He, Lizhen; Shi, Changzheng; Zhang, Dong; Liu, Yiyong; Luo, Liangping; Chen, Tianfeng
• Is Part Of: Dalton transactions. Volume 48:Issue 5(2019)
• Page Start: 1569
• Page End: 1573
• Publication Date: 2018-11-30
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/c8dt03948h
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : Herein we synthesize a cell penetrating peptide- and cancer-targeted molecule-functionalized multi-walled carbon nanotube for precise orthotopic glioma therapy. Abstract : Herein we designed and synthesized a cell penetrating peptide- and cancer-targeted molecule-functionalized multi-walled carbon nanotube for precise orthotopic glioma therapy. In addition to reduced toxicity, this nanosystem exhibited enhanced cancer recognition, blood–brain barrier (BBB) penetration, and anticancer activity through increased ROS production.