Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials. (17th December 2018)

• Record Type: Journal Article
• Authors: Ruskowitz, Emily R.; Comerford, Michael P.; Badeau, Barry A.; DeForest, Cole A.
• Is Part Of: Biomaterials science. Volume 7:Number 2(2019)
• Page Start: 542
• Page End: 546
• Publication Date: 2018-12-17
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c8bm01304g
• Languages: English
• ISSNs: 2047-4830

Abstract

Abstract : Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic. Abstract : Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates.