Logical stimuli-triggered delivery of small molecules from hydrogel biomaterials. (17th December 2018) - Ruskowitz, Emily R.
Abstract : Triggered release of small molecule model therapeutics from hydrogel biomaterials is governed by user-programmable Boolean logic. Abstract : Stimuli-responsive biomaterials are useful platforms for environmentally triggered drug delivery. By varying the molecular architecture of orthogonal stimuli-labile linkages between small molecules and non-degradable materials, we demonstrate the Boolean logic-based release of model therapeutics from gels. Programmable responses are demonstrated for materials sensitive to input combinations involving enzymes, chemical reductants, and light via YES, OR, and AND logic gates.