Lactulose synergizes with CpG-ODN to modulate epithelial and immune cells cross talk. Issue 1 (11th January 2019)

• Record Type: Journal Article
• Authors: Mukherjee, R.; van de. Kaa, M.; Garssen, J.; Pieters, R. J.; Kraneveld, A. D.; Willemsen, L. E. M.
• Is Part Of: Food & function. Volume 10:Issue 1(2019)
• Page Start: 33
• Page End: 37
• Publication Date: 2019-01-11
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c8fo02376j
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Apart from being a prebiotic and laxative, lactulose has direct immunomodulatory effects. Abstract : Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.