A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities. Issue 6 (2nd January 2019)

• Record Type: Journal Article
• Authors: Zhao, Xuan; Huang, Yuchao; Yuan, Gankun; Zuo, Ke; Huang, Yafan; Chen, Juanjuan; Li, Jinyu; Xue, Jinping
• Is Part Of: Chemical communications. Volume 55:Issue 6(2019)
• Page Start: 866
• Page End: 869
• Publication Date: 2019-01-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc09456j
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A novel effective dual-targeted photosensitizer based on phthalocyanine can precisely target the mitochondria of EGFR overexpressing cancer cells. Abstract : We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc ), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity ofG-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.