A novel tumor and mitochondria dual-targeted photosensitizer showing ultra-efficient photodynamic anticancer activities. Issue 6 (2nd January 2019) - Zhao, Xuan
Abstract : A novel effective dual-targeted photosensitizer based on phthalocyanine can precisely target the mitochondria of EGFR overexpressing cancer cells. Abstract : We designed and synthesized a simple, but highly effective photosensitizer (G-Mito-Pc ), which can precisely target the mitochondria of epidermal growth factor receptor (EGFR)-overexpressing cancer cells, to achieve dual targeting function at both cell and organelle levels in cancer therapy. We further explored the possible molecular mechanism of the enhanced bioactivity ofG-Mito-Pc compared to that of the reference photosensitizer using molecular dynamics simulations on their interactions with a physiologically relevant mitochondrial membrane model.