Acute effect of fish protein hydrolysate supplementation on vascular function in healthy individuals. (July 2018)

• Record Type: Journal Article
• Authors: Alvares, Thiago Silveira; Conte-Junior, Carlos Adam; Pierucci, Anna Paola; de Oliveira, Gustavo Vieira; Cordeiro, Elisaldo Mendes
• Is Part Of: Journal of functional foods. Volume 46(2018)
• Page Start: 250
• Page End: 255
• Publication Date: 2018-07
• Subjects: BBD baseline brachial artery diameter -- EAA essential amino acids -- FMD, flow-mediated dilatation -- FPH fish protein hydrolysate -- NIRS near-infrared spectroscopy -- PBD peak brachial artery diameter -- PLA placebo -- StO2 tissue O2 saturation -- StO2 base baseline tissue O2 saturation -- StO2 slope_1 tissue O2 desaturation rate -- StO2 min minimum tissue O2 saturation -- StO2 slope_2 tissue O2 resaturation rate -- StO2 max maximal tissue O2 saturation -- StO2 tmax time to maximal tissue O2 saturation -- TAC total antioxidant capacity -- TEAC trolox equivalent antioxidant capacity -- VOT vascular occlusion test; Fish protein -- Functional food -- Flow-mediated dilatation -- Near-infrared spectroscopy -- Vascular healthy; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2018.04.066
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: The development of fish protein hydrolysate (FPH) as functional food is a relatively recent technology gaining in popularity due to the array of potential bioactive properties associated with them, including antioxidant and antihypertensive properties. The effect of a single oral dose of the FPH on vascular function (macro and microvascular function) in humans was investigated. A single dose of the FPH supplement (5 g) did not cause significant changes in the parameters of macrovascular and microvascular function in the participants. Highlights: A FPH supplement was developed from fish waste. The vascular effects of FPH were studied in humans. FPH demonstrated high protein content and antioxidant capacity. FPH supplementation does not improve vascular function. Abstract: Fish protein hydrolysates (FPH) have demonstrated in vitro anti-hypertensive and antioxidant properties. Since hypertension and oxidative stress are key factors for endothelial dysfunction, the main purpose of the present study was to investigate the effect of FPH on vascular function. Participants consumed 5 g of FPH or a placebo (PLA) supplement. Flow-mediated dilation (FMD) and tissue O2 saturation (StO2 ) were taken at different time points over 130 min after nutritional intervention. The FPH had 80.6 ± 1.0% of protein and the major amino acid present in the FPH was glutamic acid, followed by aspartic acid and histidine. There was no significant change in FMD as well as no significant change in the StO2 parameters between FPH and PLA supplementation. Although FPH has been shown to be a valuable source of protein, essential amino acids and antioxidants, a single dose did not promote significant changes on vascular function in healthy individuals.