An Intestinal Inflammasome – The ILC3–Cytokine Tango. Issue 4 (April 2016)

• Record Type: Journal Article
• Authors: Gonçalves, Pedro; Di Santo, James P.
• Is Part Of: Trends in molecular medicine. Volume 22:Issue 4(2016)
• Page Start: 269
• Page End: 271
• Publication Date: 2016-04
• Subjects: microbiota -- metabolites -- inflammasome -- IL-18 -- innate lymphoid cells -- IL-22; Molecular biology -- Periodicals; Pathology, Molecular -- Periodicals; Physiology, Pathological -- Periodicals; 572.8
• DOI: 10.1016/j.molmed.2016.02.008
• Languages: English
• ISSNs: 1471-4914

Abstract

Abstract : The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.