An Intestinal Inflammasome – The ILC3–Cytokine Tango. Issue 4 (April 2016) - Gonçalves, Pedro
Abstract : The inflammasome is a key regulator of immune responses in the gut. Two recent studies in the journal Cell demonstrate that epithelial inflammasome activation and IL-18 secretion can control intestinal homeostasis or induce autoinflammation. ILC3 cells are triggered to secrete IL-22, regulating IL-18 expression in epithelial cells, in turn modulating homeostasis and inflammation.