A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers. Issue 11 (1st November 2018)

• Record Type: Journal Article
• Authors: Martínez-Maqueda, Daniel; Zapatera, Belén; Gallego-Narbón, Angélica; Vaquero, M. Pilar; Saura-Calixto, Fulgencio; Pérez-Jiménez, Jara
• Is Part Of: Food & function. Volume 9:Issue 11(2018)
• Page Start: 6010
• Page End: 6019
• Publication Date: 2018-11-01
• Subjects: Food -- Analysis -- Periodicals; Food -- Composition -- Periodicals; Nutrition -- Periodicals; 664.07
• DOI: 10.1039/c8fo01323c
• Languages: English
• ISSNs: 2042-6496

Abstract

Abstract : Cardiometabolic effects of supplementation in a clinical trial with dried grape pomace at a realistic dose, a product rich in less-studied non-extractable polyphenols. Abstract : Grape polyphenols have shown a promising role in the modulation of metabolic syndrome (MetS), mostly in animal models. However, clinical studies are scarce and they usually only consider a fraction of polyphenols, ignoring the non-extractable polyphenols (high molecular weight compounds or associated with macromolecules such as dietary fibre). This study aimed at evaluating the effect of grape pomace, rich in both extractable and non-extractable polyphenols, on markers of MetS. Fifty subjects (22 women) aged 20–65 with at least two MetS factors were randomly assigned to the product (daily dose of 8 g of dried grape pomace) or to the control group in a 6 week crossover design with a 4 week wash-out. Samples were collected at the beginning and at the end of both periods; half of the participants were subjected to an oral glucose tolerance test at the beginning and the end of the supplementation period. Grape pomace supplementation significantly improved fasting insulinaemia ( p < 0.01), without affecting other cardiometabolic risk parameters. A tendency towards an improvement in postprandial insulinaemia was observed, particularly in those subjects with higher fasting insulin levels. Therefore, supplementation with grape pomace may be a strategy for improving insulin sensitivity in subjects at high cardiometabolic risk.