Biomedical Applications: Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo (Adv. Mater. 4/2014). (23rd January 2014)

• Record Type: Journal Article
• Authors: Nelson, Christopher E.; Kim, Arnold J.; Adolph, Elizabeth J.; Gupta, Mukesh K.; Yu, Fang; Hocking, Kyle M.; Davidson, Jeffrey M.; Guelcher, Scott A.; Duvall, Craig L.
• Is Part Of: Advanced materials. Volume 26:Number 4(2014)
• Page Start: 506
• Page End: 506
• Publication Date: 2014-01-23
• Subjects: gene knockdown -- controlled release -- reversible addition‐fragmentation chain transfer (RAFT) polymerization, endosomolytic nanoparticles, injectable scaffolds; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201470023
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : On page 607, C. L. Duvall and co‐workers detail a new technology for sustained, local delivery of siRNA. The authors apply this platform to manipulate activity of a pro‐angiogenic transcription factor, which orchestrates robust biomaterial scaffold neovascularization in vivo. This system may provide a superior approach to traditional pro‐angiogenic therapies and holds promise for broader application in regenerative medicine.