1, 2, 3-Triazole N(2)-chelated C–S coupling: Access to ortho methylthiolated 1, 2, 3-triazoles. Issue 19 (2nd October 2018)

• Record Type: Journal Article
• Authors: Yu, Shengtao; Liu, Yaowen; Wang, Jiazhuang; Luo, Fang; Cheng, Huiling; Jiang, Yubo
• Is Part Of: Synthetic communications. Volume 48:Issue 19(2018)
• Page Start: 2566
• Page End: 2574
• Publication Date: 2018-10-02
• Subjects: CuF2-mediated -- DMSO -- methylthiolation -- 1, 2, 3-triazoles; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2018.1514050
• Languages: English
• ISSNs: 0039-7911

Abstract

Abstract: CuF2 -mediated selective C-S coupling of 1, 4-disubstituted 1, 2, 3-triazole halides using the widely available DMSO as the methylthiolation reagent were achieved through the chelation of N(2) atom in triazole ring. The ortho- C-halogen bond in N(1) aryl was selectively coupled, while other C-halogen bonds remained, generating 1, 4- disubstituted 1, 2, 3-triazoles bearing aryl methyl thioether fragment. Graphical Abstract: