1, 2, 3-Triazole N(2)-chelated C–S coupling: Access to ortho methylthiolated 1, 2, 3-triazoles. Issue 19 (2nd October 2018) - Yu, Shengtao
Abstract: CuF2 -mediated selective C-S coupling of 1, 4-disubstituted 1, 2, 3-triazole halides using the widely available DMSO as the methylthiolation reagent were achieved through the chelation of N(2) atom in triazole ring. The ortho- C-halogen bond in N(1) aryl was selectively coupled, while other C-halogen bonds remained, generating 1, 4- disubstituted 1, 2, 3-triazoles bearing aryl methyl thioether fragment. Graphical Abstract: