Azacalixphyrins as NIR photoacoustic contrast agents. Issue 87 (16th October 2018)

• Record Type: Journal Article
• Authors: Lavaud, Lucien; Pascal, Simon; Metwally, Khaled; Gasteau, Damien; Da Silva, Anabela; Chen, Zhongrui; Elhabiri, Mourad; Canard, Gabriel; Jacquemin, Denis; Siri, Olivier
• Is Part Of: Chemical communications. Volume 54:Issue 87(2018)
• Page Start: 12365
• Page End: 12368
• Publication Date: 2018-10-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c8cc05851b
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Newly designed aryl-substituted azacalixphyrins are promising contrast agents for photoacoustic imaging upon excitation in the 800–1000 nm NIR range. Abstract : Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N -alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800–1000 nm range.