Azacalixphyrins as NIR photoacoustic contrast agents. Issue 87 (16th October 2018) - Lavaud, Lucien
Abstract : Newly designed aryl-substituted azacalixphyrins are promising contrast agents for photoacoustic imaging upon excitation in the 800–1000 nm NIR range. Abstract : Near-infrared (NIR) azacalixphyrins bearing aryl substituents strongly impacting the physico-chemical properties of the macrocycles were designed, enabling hyperchromic and bathochromic shifts of the absorption compared to their N -alkylated analogues. This engineering enhances the photoacoustic response under NIR excitation, making azacalixphyrins promising organic contrast agents that reach the 800–1000 nm range.